Tight transmission bottlenecks may limit the evolution of SARS-CoV-2 variants

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Tight transmission bottlenecks may limit the evolution of SARS-CoV-2 variants
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Tight transmission bottlenecks may limit the evolution of SARS-CoV-2 variants NaturePortfolio UMich TransmissionBottleneck Variant SARSCoV2 COVID19 VariantsofConcern

By Dr. Sanchari Sinha Dutta, Ph.D.Jan 18 2023Reviewed by Aimee Molineux A study published in Nature Communications describes that tight transmission bottlenecks restrict the evolution of severe acute respiratory syndrome coronavirus 2 in the transmission chain. SARS-CoV-2 is the causative pathogen of the coronavirus disease 2019 pandemic.

Therefore, tight transmission bottlenecks restrict the adaptive evolution of a virus by preventing the onward spread of newly accumulated mutations. Tight transmission bottlenecks have previously been observed for many viruses, including human immunodeficiency virus , influenza virus, and SARS-CoV-2.

Genetics & Genomics eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Based on the sequencing results, the final transmission analysis included 45 households, 110 individuals, and 134 possible transmission pairs. The SARS-CoV-2 variants of concern identified in these households were alpha, beta, delta, and omicron.

Transmission bottleneck The genetic diversity shared between the household members of a transmission pair was used to calculate the transmission bottleneck. Within a household, a transmission pair includes the index case as the donor and the contact as the recipient.

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