Researchers reveal genetic predisposition to immunity against new variants of COVID-19 thePeerJ
Acquired immunity to infections is largely provided by T lymphocytes—cells of the immune system which detect foreign antigens after infection and trigger an immune response. This is the role of T cell receptors , special receptors on the T cell surface.
An individual's set of HLA-I genes is unique. This is the main reason why viral infections affect people with varying degrees of severity. In particular, as HSE researchers have previously demonstrated, the individual HLA-I genotype determines predisposition to severe forms of COVID-19. The researchers performed HLA typing by next-generation sequencing that identifies the variant forms of genes in a particular individual. The scientists then compared the frequency of alleles' occurrence between the patient groups.in the third wave as in the first wave. Other variants of HLA-I genes were equally common in both groups.
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