The international BRACE trial, investigating the BCG vaccine's efficacy against COVID-19, has found it does not reduce healthcare workers' risk of contracting the disease. Future studies will explore the vaccine's influence on other infections and COVID-19 vaccine responses. A world-leading inter
The international BRACE trial, investigating the BCG vaccine’s efficacy against COVID-19, has found it does not reduce healthcare workers’ risk of contracting the disease. Future studies will explore the vaccine’s influence on other infections and COVID-19 vaccine responses., has found it does not reduce healthcare workers’ risk of contracting the disease. Future studies will explore the vaccine’s influence on other infections and COVID-19 vaccine responses.
The BRACE trial was built on previous research, which showed BCG also boosted ‘front-line’ immunity in infants and protected against respiratory infections in adolescents and adults. It was hoped the vaccine could be repurposed to buy crucial time in a pandemic like COVID-19 until disease-specific vaccines were developed and tested.
“When we analyzed the immune cells from our healthcare workers, we saw that the BCG vaccine altered the immune response to COVID-19,” he said.. A stronger response induced by BCG could be beneficial in killing the virus more rapidly and protecting against progression to more severe disease. There was some evidence of this in trial participants over the age of 60, in whom COVID-19 symptoms were shorter in the BCG-vaccinated group.
“The findings raise important questions about how BCG can modify the course of different viral illnesses and allows us to develop a fuller understanding of whether the vaccine can provide protection against a range of infections other than its main target, tuberculosis,” he said. Professor Curtis said trials of this size and complexity normally took about eight to 12 months to organize and recruit, but BRACE was able to start within three weeks due to the dedicated researchers and support teams at the Murdoch Children’s, together with generous philanthropic support.
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