This article explores growth factors and cytokines to boost dendritic cell proliferation and differentiation.
Sponsored Content by ACROBiosystemsApr 2 2024Reviewed by Aimee Molineux Dendritic cells are exceptionally potent antigen-presenting cells in the human body and are considered the “sentinels” of the immune system. They are essential in establishing, maintaining, and strengthening innate and adaptive immune responses. They interact with various immune cells like T and B cells, increasing the efficacy of immune responses.
DC cell therapy: An ex vivo approach for DC vaccination In this method, monocytes are first isolated from the patient's blood, or CD34+ precursor cells are collected from the bone marrow. Cells are then stimulated and differentiated using a variety of cytokines, prompting the creation of immature dendritic cells . These immature DCs are filled with antigens, including nucleic acids to peptides, proteins, cells, or nanoparticles, using methods like cell fusion, co-culture, or transfection.
However, growth factors, including TNF-α, IFN-β, IFN-γ, IL-6, and PGE2, are required to prompt differentiation into mature CD1a+CD83+ DCs for use in the following cell therapy production processes. In addition, DCVax-L has shown promise for treating glioblastoma in Germany. These vaccines use a patient's DCs, filled with tumor antigens, to provoke an immune response against cancer.
Research in the last two decades on DC vaccines/cell therapy has taken extraordinary steps in improving the migratory abilities and immune effectiveness of DCs.
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