Set up reservelab capacity now for faster response to the next pandemic, say researchers Cambridge_Uni bmj_latest
Researchers say a"human bottleneck," due to historical cuts in public health funding, delayed the UK's scale-up of COVID-19 testing in the early stages of the country's pandemic response.
"Because COVID-19 testing wasn't scaled up quickly enough, we couldn't detect all cases quickly enough to try and stop the spread of the disease," said Dr. Jordan Skittrall in the University of Cambridge's Department of Pathology and first author of the report. The researchers say that the risk of another pandemic like COVID-19 happening is ever-present: There have been outbreaks of infectious disease throughout history. But nobody can say for sure when it will happen.
As a clinician at Addenbrooke's Hospital in Cambridge, Skittrall put his normal work on hold to help interpret COVID-19 test results in the lab in early 2020, and ensure the right clinical responses were carried out.
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Long-term neuromuscular consequences of SARS-Cov-2 and their similarities with myalgic encephalomyelitis/chronic fatigue syndrome: results of the retrospective CoLGEM study - Journal of Translational MedicineBackground Patients with long-COVID often complain of continuous fatigue, myalgia, sleep problems, cognitive dysfunction, and post-exertional malaise. No data are available on EMG recording of evoked myopotentials (M-waves) or exercise-induced alterations in long-COVID patients, providing evidence of muscle membrane fatigue. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) develops in more than half of patients after an infectious disease, particularly viral diseases. A large proportion (around 70%) of these patients have neuromuscular disorders with M-wave alterations during and after exercise. Our hypothesis was that M-wave alterations would be also found in long-COVID patients, in association with neuromuscular symptoms, similar to ME/CFS. Methods This retrospective observational ColGEM (Covid LonG Encéphalomyelite Myalgique) study compared 59 patients with long-COVID and 55 ME/CFS patients with a history of severe infection who presented before the COVID pandemic. All of these patients underwent the same protocol consisting of a questionnaire focusing on neural and neuromuscular disorders and M-wave recording in the rectus femoris muscle before, during, and 10 min after a progressive cycling exercise. Maximal handgrip strength (MHGS) and maximal exercise power were also measured. The frequency of symptoms and magnitude of M-wave changes in the two groups were compared using non-parametric and parametric tests. Results The frequency of fatigue, myalgia, sleep problems, cognitive dysfunction, and post-exertional malaise as well as the magnitude of exercise-induced M-wave alterations were the same in the two groups. By contrast, digestive problems were less present in long-COVID. M-wave alterations were greater in ME/CFS patients as in those with long-COVID when the highest muscle strength and highest exercise performance were measured. Conclusions These high clinical and biological similarities between long-COVID and ME/CFS support the hypothesis that S
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Observing SARS-CoV-2 Omicron reinfections with different sub-variantsObserving SARS-CoV-2 Omicron reinfections with different sub-variants SARSCoV2 COVID19 Omicron Reinfection CDCgov
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Remdesivir resistance in transplant recipients with persistent COVID-19The medical community currently lacks robust data regarding the incidence, prevalence, and clinical significance of mutations associated with resistance to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) therapeutics. This report describes two renal transplant recipient...
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Trial tests efficacy and safety of NVX-CoV2373 COVID-19 vaccine among adolescentsIn a recent study posted to the medRxiv* preprint server, researchers in the United States described the safety, efficacy, and immunogenicity of the NVX-CoV2373 vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), tested in PREVENT-19 — a phase 3, randomized, placebo-controlled, observer-blinded trial among 12- to 17-year-old adolescents in the United States (U.S).
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Study of 9 million Swedes shows rapidly declining effectiveness of COVID vaccines against OmicronThe findings of a new Swedish study posted to the Preprints with The Lancet* server found that two COVID-19 vaccine doses provided effective long-term protection against infection before Omicron, but less protection against Omicron infection (dropping to 43% by week four and no protection by week 14).
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Barbados drops all Covid entry rulesThe lifting of Covid entry requirements are expected to boost tourism to the popular Caribbean holiday destination during the winter season
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