Trial tests efficacy and safety of NVX-CoV2373 COVID-19 vaccine among adolescents Adolescents Efficacy Vaccine Coronavirus Disease COVID19 NVXCoV2373 Novavax UMmedschool UNC_SOM UWMedicine medrxivpreprint
Study: Safety, Immunogenicity and Efficacy of NVX-CoV2373 in Adolescents in PREVENT-19: A Randomized, Phase 3 Trial. Image Credit: Tikhonova Yana / Shutterstock
About the study In the present study, the phase 3 trials for the NVX-CoV2373 vaccine were carried out, first in adults in the U.S. and Mexico, and then in adolescents in the U.S. between April and June 2021, when the SARS-CoV-2 Delta variant was predominant. Related StoriesVaccine efficacy was determined based on reports by parents or guardians at the onset of mild, moderate, or severe COVID-19 symptoms. Reverse transcriptase polymerase chain reaction tests were used to confirm COVID-19. Whole-genome sequencing of the positive RT-PCR samples with sufficient viral load was carried out for lineage assignment. Geometric mean titers and geometric mean fold rise were used to calculate immunogenicity.
Neutralizing antibody GMT, serum IgG levels specific to wildtype SARS-CoV-2 and recently emerged variants, and hACE2 RBI antibodies were all higher in the vaccine group than in the placebo group.
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