Researchers identify potent pan-sarbecovirus antibodies from non-human primates vaccinated with an AS03 adjuvanted subunit SARS-CoV-2 vaccine biorxivpreprint Stanford scrippsresearch UNC ULLafayette vaccine vaccinated SARSCoV2
By Bhavana KunkalikarJan 24 2023Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the bioRxiv* preprint server, researchers assessed the effectiveness of pan-sarbecovirus-neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 .
About the study In the present study, researchers detected strong pan-sarbecovirus antibodies among non-human primates vaccinated against SARS-CoV-2 with a subunit vaccine adjuvanted with AS03. The top 206 SARS-CoV-2 Omicron BA.1-binding monoclonal antibodies were then selected for neutralization screening compared to the pseudotyped SARS-CoV-2 Wuhan strain and the BA.1 and BA.4/5 sublineages. The team also evaluated the neutralization activities as a function of time after vaccination to see if antibody maturation with respect to cross-reactivity or binding translated into increased neutralizing breath or potency.
The vaccine comprising the Wuhan strain showed that the mean potency of neutralizing antibodies against the BA.1 and BA.4/5 lineages was remarkably lower than the Wuhan strain. Over 1.5 years, the frequency observed for SARS-CoV-2 Wuhan strain and BA.1 and BA.4/5 sublineages triple-neutralizing antibodies increased significantly, while the proportion of non-neutralizing antibodies decreased, indicating a development in neutralization breadth and potency.
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