New data from the KEYNOTE-756 phase 3 clinical trial show that adding the immunotherapy drug, pembrolizumab, to chemotherapy before and after surgery for breast cancer leads to better outcomes for patients regardless of their age or menopausal status.
Mar 20 2024European Organisation for Research and Treatment of Cancer
Professor Javier Cortés, Director of the International Breast Cancer Centre in Barcelona, Spain, said: "We have already reported that there was a statistically significant increase in the pathological complete response rate in patients receiving pembrolizumab compared to those receiving the placebo. The pathological complete response rate, meaning that no cancer cells remained in the breast or lymph nodes, was 24.3% in patients treated with pembrolizumab compared to 15.
The study found there were similar rates of breast-conserving surgery and mastectomy in both groups. Among the patients who had breast-conserving surgery, 41.3% received pembrolizumab and 43.7% received placebo. Among those who had a mastectomy, 55.3% were treated with pembrolizumab and 54.4% had the placebo."
When the researchers looked at the effect of pembrolizumab according to whether patients had cancer that was ER positive in less than 10% of cells or in 10% or more, they found that 64.7% of patients with less than 10%, who were treated with pembrolizumab, had an RCB status of 0-1, compared to 37.2% of patients treated with placebo . In patients with 10% or more ER positive cells, 33.3% compared to 22.7% had an RCB 0-1 status .
Adverse events from the treatments were unchanged from previous reports from the trial and were consistent with what is known already about each regimen.
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New data show pembrolizumab improves breast cancer outcomes regardless of age or menopausal statusNew data from the KEYNOTE-756 phase 3 clinical trial show that adding the immunotherapy drug pembrolizumab to chemotherapy before and after surgery for breast cancer leads to better outcomes for patients regardless of their age or menopausal status.
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