In 2021, a Northwestern University-led research team received a Defense Advanced Research Projects Agency (DARPA) contract worth up to $33 million to develop an implantable 'living pharmacy' to control the human body's sleep/wake cycles.
Nov 9 2023 Northwestern University In 2021, a Northwestern University -led research team received a Defense Advanced Research Projects Agency contract worth up to $33 million to develop an implantable " living pharmacy " to control the human body's sleep/wake cycles . Now, the researchers have completed a major step toward achieving this goal.
In new experiments, the novel device kept cells alive for close to a month in low oxygen conditions in vitro or for weeks in vivo. Without ecO2, only about 20% of cells were alive after 10 days, but the researchers hypothesize that the cells would lose their ability to secrete drugs long before that. With advances in wireless power and communication, the researchers are confident that chronic operation over multiple months or more is within reach.
Related StoriesCombining synthetic biology with bioelectronics, Northwestern leads a collaboration with Rice University biomedical engineering professor Omid Veiseh to produce the therapeutics on site within the device. Keeping these engineered cells alive is a crucial step in the development of these potentially life-saving devices.
"It is as simple as a Chemistry 101 experiment we all did as kids," Rivnay said. "You pass electricity through water and bubbles form at the metals, and the water splits into oxygen and hydrogen. We are doing this but in a smarter manner. Using unique materials allows more efficient and low energy production of oxygen. And in our device, we aren't forming oxygen bubbles.
Northwestern University Implantable Device Living Pharmacy Sleep/Wake Cycles Oxygen Production
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A breath of fresh air keeps drug-producing cells alive longerIn 2021, a Northwestern University-led research team began working to develop an implantable 'living pharmacy' to control the human body's sleep/wake cycles. Now, the researchers have completed a major step toward achieving this goal.
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