The safety and efficacy of treating human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer with pyrotinib.
By Dr. Chinta SidharthanNov 2 2023Reviewed by Lily Ramsey, LLM In a recent study published in the BMJ Journal, a team of scientists from China investigated the safety and efficacy of treating human epidermal growth factor receptor 2 -positive metastatic breast cancer with pyrotinib, a pan-HER inhibitor, in combination with docetaxel and trastuzumab, and compared it to that of a variety of a placebo, docetaxel, and trastuzumab.
Evidence from various studies also indicates that using two agents targeting HER-2 through differing mechanisms of action has proven more effective than using just one anti-HER-2 agent. Females between the ages of 18 and 75 with metastatic or recurrent breast cancer that was HER-2 positive, confirmed through histological tests such as immunohistochemistry or in situ hybridization, were eligible for the trial.
Computed tomography or magnetic resonance imaging was used to assess the tumors at baseline, every nine weeks during the first 18 months, and after that every 12 weeks. Results The results indicated that pyrotinib, in combination with docetaxel and trastuzumab, was effective in increasing the progression-free survival rate of patients with untreated, HER-2-positive breast cancer.
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