Pancreatic cancer is difficult to diagnose because symptoms do not often appear during the early stages of the disease when surgery is still an option - via healthing_ca healthing Canada Cancer
Pancreatic cancer has the lowest five-year relative survival rate of all major cancer killers and is the only one for which both the incidence and death rates are rising.Pancreatic cancer is difficult to diagnose because symptoms do not often appear during the early stages of the disease when surgery is still an option. GETTY
A new screening tool successfully detected 95.5 per cent of stage 1 pancreatic cancers in a pilot study that offers some much-needed hope to patients affected by the devastating disease and other difficult-to-diagnose cancers., was also able to identify 74.4 per cent of stage 1 ovarian cancers and 73.1 per cent of pathologic stage 1A lethally aggressive serous ovarian adenocarcinomas — all with 99 per cent specificity.
The pilot study, which included 139 stage 1 and 2 cancer patients and 184 controls, was the first clinical test of the new technology, known as high-conductance di-electrophoresis. The platform works by identifying extracellular vesicles containing tumour proteins that are released into circulation by cancer cells. Artificial intelligence is used to analyze markers for these proteins and predict the probability of malignancy.
While liquid biopsies are an effective method of monitoring cancer, they are not always ideal for early detection. “They can cause real harm to otherwise healthy people when used for early-disease screening due to unacceptably high false-positive rates that lead to diagnostic tests that are not only expensive but often dangerous,” Lippman said.
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