About 60 percent of women taking zuranolone felt a 50 percent or better improvement in their depressive symptoms after two weeks. The neuroactive steroid could be FDA approved by August.
According to findings from the double-blind study published in the, approximately 200 women taking a 50-milligram dose for two weeks experienced significant improvements in depressive symptoms. Around 60 percent of those taking zuranolone reported a 50 percent or better improvement in their depressive symptoms after two weeks, with some participants reporting a difference in as little as three days.
How are such quick results possible? Unlike anti-depressents, most of which are slow-acting selective serotonin reuptake inhibitors , zuranolone, is a version of a naturally occurring substance in the body called allopregnanolone—a neuroactive steroid that is a metabolizes the hormone progesterone. Levels of allopregnanolone can rise dramatically during pregnancy and then abruptly drop after childbirth, potentially contributing to postpartum depression.
“Neuroactive steroids are naturally made in the brain and are breakdown products of progesterone that protect brain networks from the damaging effects of stress and maintain healthy brain network functioning,” Dr. Kristina Deligiannidis, the lead author of both studies told“It saved my life. It saved my marriage. It saved my kids,” Sahar McMahon, a member of the trial study, said of her experience taking zuranolone.
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