The new phase three trial suggests that zuranolone might offer a quick and effective oral treatment for postpartum depression across diverse groups of women.
For Sahar McMahon, having her second baby was a completely different experience than having her first. Her postpartum negative mood, low energy and inability to focus were feelings that she had never felt before. With her first daughter, Ophelia, McMahon downloaded an app to her phone to excitedly track the baby’s month-by-month development, and the pair often would go on playdates with friends. But with her second daughter, Lenora, McMahon felt no motivation to leave their home.
As the researchers continued to follow the women through 45 days, 61.9% of participants who received zuranolone, compared with 54.1% of those taking a placebo, reported a 50% or higher improvement in their depressive symptoms. Some of the women given zuranolone reported drowsiness, dizziness or sedation. Among the 98 who were given zuranolone, 16 reduced their dosage from 50 to 40 milligrams due to those side effects.
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