Nanoplatforms in Imaging-Guided Brain Tumor Treatment ADDReditors nanomedicine cancer optics nanooptics nanoplatform nanoscience
By Bhavna KavetiSep 15 2022Reviewed by Susha Cheriyedath, M.Sc. Malignant brain tumors are cancerous growth in the brain with the possibility of spreading to other parts of the central nervous system . Brain tumors are highly invasive and have devastating consequences, poor prognosis, and low survival rates.
Finally, the opportunities and challenges involved in the use of CAs and nanotheranostics for future clinical translation were discussed. Related StoriesIn this regard, fluorescence imaging is a method that relies on fluorescence, absorption, bioluminescence, and reflectance resulting from various fluorescent nanomaterials used for visualizing the brain microstructures and monitoring the tumor progression.
Similarly, near-infrared photoacoustic imaging is a noninvasive imaging technique that involves acoustic waves as the emission source. It combines the advantages of ultrasonic and optical energies to realize biological imaging with deep tissue penetration depth. Thus, making PAI a promising diagnosis technique.
Near-infrared fluorescence imaging and PAI have vividly helped in the diagnosis of cancer. However, the presence of the skull and scalp hampers the quality of light and the imaging of brain tumors. This suggests that the second near-infrared region can increase tissue penetration and depth while decreasing light scattering and enhancing the signal-to-background ratio. Consequently, deep-seated brain tumors can also be diagnosed.
Furthermore, nanoparticles less than 5 nanometers in size are favorable for renal excretion and reduce toxicity during treatment. Thus, the fabrication of biodegradable nanomaterials followed by toxicity evaluations can increase the clinical success of treatment.
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