Meta-analysis reveals drivers of antibiotic resistance in infants

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Meta-analysis reveals drivers of antibiotic resistance in infants
Antibiotic ResistanceGeneticAntimicrobial Resistance
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A meta-analysis of genetic studies analyzing the microbiota (bacteria in the gut) of 1,275 infants from 10 countries finds that cesarean delivery and antibiotic use are driving the increase of antibiotic resistance genes load among infants, according to new research being presented at this year's ESCMID Global Congress (formerly ECCMID) in...

Apr 24 2024ESCMID Global Congress A meta-analysis of genetic studies analyzing the microbiota of 1,275 infants from 10 countries finds that cesarean delivery and antibiotic use are driving the increase of antibiotic resistance genes load among infants, according to new research being presented at this year's ESCMID Global Congress in Barcelona, Spain .

The gut mobilome-;the collection of diverse mobile genetic elements within the gut, plays a key role in the spread of ARGs. Bacteria swap genetic material, like ARGs, through horizontal gene transfer. With so many bacteria in close proximity, the gut provides ideal conditions for this exchange of ARGs.

To overcome these limitations, researchers conducted a meta-analysis of infant cohorts based on metagenomics data from 14 studies spanning 10 countries and three continents. On the other hand, vaginal birth was linked to lower abundance but more diverse ARGs compared to C-section delivery.

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Antibiotic Resistance Genetic Antimicrobial Resistance Bacteria Cancer C-Section E. Coli Gene Genes Global Health Microbiome Probiotics Research Vaginal

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Antibiotic resistance in babies varies according to mode of birth, prematurity and where they live, says analysisAntibiotic resistance in babies varies according to mode of birth, prematurity and where they live, says analysisA meta-analysis of genetic studies analyzing the microbiota (bacteria in the gut) of 1,275 infants from 10 countries finds that cesarean delivery and antibiotic use are driving the increase of antibiotic resistance genes load among infants, according to new research being presented at this year's ESCMID Global Congress (formerly ECCMID) in...
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