Investigating an effective linear deoxyribonucleic acid COVID-19 vaccine option for domestic cats biorxivpreprint SARSCoV2 COVID19 Vaccination Vaccine Feline
By Shanet Susan AlexJul 27 2022Reviewed by Aimee Molineux In a recent article posted to the bioRxiv* preprint server, investigators studied a linear deoxyribonucleic acid severe acute respiratory syndrome coronavirus 2 vaccine option in felines.
About the study In the current research, the scientists presented findings from a randomized Phase 1/2 clinical trial in domestic cats using a nucleic acid-based COVID-19 vaccine made of polymerase chain reaction -based linDNA. They evaluated the immunogenicity and safety of the linDNA vaccine that contained the SARS-CoV-2 receptor-binding domain . Moreover, the vaccine was delivered utilizing electro-gene transfer .
Related StoriesFurther, the investigators conducted a randomized phase 1/2 clinical investigation comprising 11 domestic cats to evaluate the effectiveness of the linDNA vaccine in an animal species predisposed to SARS-CoV-2 infection. The vaccination protocol involved administering 1 mg of linDNA intramuscularly twice, on days 0 and 28, and then immediately electroporating the co-localized intramuscular region of each rear leg's tibialis cranialis.
Notably, the linDNA COVID-19 vaccine option demonstrated immunogenicity by inducing binding and neutralizing antibodies, the latter of which is necessary to safeguard against live viral infection shortly after priming against the S RBD of the SARS-CoV-2 ancestral strain and three SARS-CoV-2 variants . In addition, compared to those found against the B.1.526 and P.1 variants, neutralizing titers evaluated against the ancestral SARS-CoV-2 and B.1.1.7 strains were drastically elevated.
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