A new study from Karolinska Institutet in Sweden reveals that immune cells in the liver react to high cholesterol levels and eat up excess cholesterol that can otherwise cause damage to arteries.
Mar 11 2024Karolinska Institutet The findings, published in Nature Cardiovascular Research, suggest that the response to the onset of atherosclerosis begins in the liver.
The liver responded immediately In the current study, researchers wanted to understand how different tissues in the body react to high levels of LDL, also called 'bad cholesterol', in the blood. To test this, they created a system where they could quickly increase the cholesterol in the blood of mice.
Stephen Malin, lead author of the study and principal researcher at the Department of Medicine, Solna, Karolinska Institutet "We were surprised to see that the liver seems to be the first line of defense against excess cholesterol and that the Kupffer cells were the ones doing the job," says Stephen Malin. "This shows that the liver immune system is an active player in regulating cholesterol levels, and suggests that atherosclerosis is a systemic disease that affects multiple organs and not just the arteries.
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