Future COVID-19 control will require vaccines that induce better mucosal immunity Immunity Coronavirus Disease COVID Vaccines medrxivpreprint INSERM univ_paris_cite institutpasteur
Study: Long-term systemic and mucosal SARS-CoV-2 IgA response and its association with persistent smell and taste disorders. Image Credit: Huen Structure Bio / Shutterstock
The team chose 133 of the 400 volunteers who completed the whole longitudinal follow-up based on participant eligibility, the lack of a new SARS-CoV-2 infection at the time of follow-up, and the quantity/quality of their saliva samples. At each follow-up visit, the clinical state of the participants was assessed.
At V1, unique anti-SARS-CoV-2 IgA was found in the saliva of infected persons, in contrast to the saliva of healthy individuals. These antibodies attacked the viral spike in its entirety, targeting the spike/RBD more than the spike/NTD, while the nucleocapsid was not targeted. In the initial six months, the amount of IgA in saliva reduced dramatically against all targets. Linear mixed models revealed negative slopes corresponding to a daily drop in IgA concentration for S by 1.
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