Pharmaceutical companies are racing to develop a coronavirus vaccine, with the most ambitious timelines ever attempted in history.
Vaccine development under normal circumstances typically takes. Now, developers are compressing the traditional timeline with both technological innovation and by putting vast amounts of money at risk.
The idea here would be to show that vaccinated participants have levels of neutralizing antibodies in their blood that are at least as high as patients naturally infected by the virus, and to greenlight the use of a vaccine based on its anticipated benefit, perhaps limited initially to some high-risk populations.
Some fear that this winter, as the annual flu season returns, there could be a"double threat" with both virusesPfizer's Dormitzer said his company will be simultaneously running a full phase 3 trial while gathering data on antibody levels in vaccinated participants."We want public health measures to reduce infection levels, but we also want a vaccine. That can create a dilemma if there aren't enough cases," he said."We need a plan B, just in case.
Dr. Paul Offit, director of the vaccine education center at the Children's Hospital of Philadelphia, noted that many approved vaccines on the market today don't have a known immune correlate."The immune response may or may not be predictive," he said."The proof is in the pudding. The pudding is the big phase 3 trial."
On the other hand,"CDC has reported that 8 in 10 deaths from the coronavirus are seniors, which is a terrible thing, so perhaps we're willing to take more risk and not wait a decade for a vaccine."
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