False positive monkeypox tests in low-risk patients with no exposures CDCgov IUMedSchool HopkinsMedicine monkeypox virus infection disease rash
By Bhavana KunkalikarSep 13 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in the Morbidity and Mortality Weekly Report, the researchers reported three monkeypox diagnoses presenting atypical rashes.
In this study, three individuals with atypical rashes were diagnosed with monkeypox based on false-positive test findings for late cycle threshold values of 34 or more who had no epidemiologic association to a monkeypox case or known risk factors. Related StoriesShe reported having varicella and receiving a smallpox immunization as a child. Testing was performed for syphilis, herpes simplex, cryptococcosis, and histoplasmosis, all of which yielded negative results. Furthermore, 53 days following the commencement of the rash, a pustular forearm lesion was swabbed, and the result of the nonvariola-orthopoxvirus test was positive.
Patient B was treated with tecovirimat because of periorbital lesions, probable ocular autoinoculation, and the potential onset of a disease that could cause blindness. The child had practiced a contact sport when the rash first appeared and shared a home with four other people. He was released from isolation when a second test on the original samples led to a negative result. The results of the enterovirus PCR test pointed to a diagnosis of hand, foot, and mouth disease.
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