Dissecting vaccinia virus and monkeypox virus-specific T cell responses in humans biorxivpreprint ljiresearch VacciniaVirus Monkeypox TCell Response
By Neha MathurSep 12 2022Reviewed by Aimee Molineux In a recent study posted to the bioRxiv* preprint server, researchers studied different antigens targeted by vaccinia virus - and monkeypox virus -specific T cells.
About the study In the present study, researchers retrieved the epitope information available on VACV vaccines in the immune epitope database to predict potential MPXV targets recognized by T cells. They developed MPs based on the most immunodominant MPXV ortholog proteins that could help assess T cell responses to VACV and predict MPXV T cell epitopes likely to be recognized by VACV-induced T cell responses.
Furthermore, the authors noted that MVA had conserved all dominant ORFs, and had orthologs in MPXV. Again, this is an important finding suggesting that MVA-induced T cell response directed to MPXV should ideally be able to mirror VACV vaccine-induced responses, with substantial clinical efficacy against MPXV in humans.
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