The study found the vaccine boosted the number of cytotoxic T cells capable of infiltrating and attacking tumor cells.
Investigators from the National Institute of Allergy and Infectious Diseases , part of the, found that the intravenous administration of the vaccine boosted the number of cytotoxic T cells capable of infiltrating and attacking tumor cells and also engaged the innate immune system by inducing type I interferon — a natural substance that helps the body's immune system fight infection and other diseases such as cancer.
"I am really cautiously optimistic that over the next several years we’ll be able to use this information to improve immune therapy against cancer," Robert Sedar said, adding, "I’m optimistic that all of this information will make tumor immune therapy more efficient.
The researchers also say the candidate vaccine might additionally be given intravenously to people who have already received tumor-specific T cells as a therapy. It could improve tumor control by increasing the number of T cells and altering the tumor microenvironment to make them function better.
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