An experimental Alzheimer's drug failed to slow cognitive decline in a long-awaited trial, marking the latest disappointment in a research field that has been wrought with setbacks.
Pharmaceutical giant Roche said Monday that its drug gantenerumab did not show any substantive cognitive and functional changes, including memory, problem-solving, and orientation among patients in the early stages of Alzheimer's disease."So many of our families have been directly affected by Alzheimer’s, so this news is very disappointing to deliver,” said Dr. Levi Garraway, Roche’s chief medical officer.
The Swiss drugmaker held two clinical trials, each with roughly 1,000 patients in early stages of the disease across 30 countries, testing gantenerumab's ability to slow the progression of the disease. Gantenerumab is a monoclonal antibody treatment that targets a type of plaque in the brain made up of the protein beta-amyloid, which accumulates in the brains of Alzheimer's patients and is thought to cause memory and cognitive problems.Last year, Biogen's Aduhelm became the first new therapy for the disease in nearly two decades to receive approval after other drug candidates failed to show positive results.
"We are seeing great progress and innovation in this class of treatment, and we learn from each trial," the Alzheimer's Association said Monday."Each anti-amyloid treatment is being tested in a different way and may act differently on the protein that is one of the hallmarks of Alzheimer’s. Research into their effectiveness and safety must continue."
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