Effects of nanoparticles on gouty arthritis in animal models of gout gout arthritis nanoparticles nano nanomedicine
By Neha MathurFeb 23 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in the BMC Musculoskeletal Disorders, researchers performed a systematic review and meta-analysis to explore the effects of nanoparticles on gouty arthritis using animal models. Based on this work, the researchers proposed testing nanomedicine-based treatment ideas for gouty arthritis in clinical studies.
They used the SYstematic Review Centre for Laboratory animal Experimentation 's risk of bias tool to assess the risk of bias in the included studies, where 'no' and 'yes' indicated a high and low risk of bias, respectively, while the remaining were tagged 'unclear'. The team considered a study high quality only when it had no more than one unclear risk.
The study results showed that though nanoparticles reduced uric acid levels in the serum of patients with gouty arthritis, they did not fetch better results than allopurinol. However, they had fewer side effects on kidney and liver functions and lipid profile and were safer for gouty arthritis patients. In addition, nanoparticles reduced joint swelling and ankle diameter.
ii) Nanoparticles improved the bioavailability of medications. For instance, a study by Win et al. showed how nanoparticles using Vitamin E-succinated polyethylene glycol 1000 emulsified in D, L-lactic-co-glycolic acid improved the therapeutic index of the paclitaxel drug formulation. In addition, nanoparticles, especially non-metals-based nanoparticles, showed better water solubility and higher bioavailability than non-metallic herbal medicines .
Overall, nanoparticles effectively reduced the toxicity of some therapeutic substances used in gouty arthritis treatment. Furthermore, the authors noted that other factors, such as the number of animals used in the studies, their species, gender, etc., also affected the nanoparticle performance. For instance, among all animals, chicken served as an ideal model for studying gouty arthritis when injected with MSU in their left ankle joint.
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