Researchers at Cedars-Sinai in Los Angeles have found the human eye can show early signals of Alzheimer's disease long before symptoms of dementia become apparent, according to a study.
of the patients with mild cognitive impairment and Alzheimer’s disease, the researchers found, had an excess amount of amyloid beta 42, a protein that forms the"plaques" that build up in the brains of people with Alzheimer’s.
Additionally, the retinas contained cells called microglia, which are also associated with progression of the disease."We discovered the accumulation of highly toxic proteins in the retinas of patients with Alzheimer’s disease and mild cognitive impairment, causing severe degeneration of cells," said Dr. Yosef Koronyo, research associate in the Cedars-Sinai Department of Neurosurgery and first author of the study, in a statement on the Cedars-Sinai website.
That's according to Maya Koronyo-Hamaoui, PhD, professor of neurosurgery, neurology and biomedical sciences at Cedars-Sinai, in a statement. "These findings may eventually lead to the development of imaging techniques that allow us to diagnose Alzheimer’s disease earlier and more accurately, and monitor its progression non-invasively by looking through the eye," said Koronyo-Hamaoui, senior author of the study.
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