While early research suggests the condition is rare, experts are still racing to answer even the most basic questions about the illness — such as why some children are more susceptible than others.
Dr. Roberta DeBiasi, the hospital's chief of pediatric infectious diseases, says staff has seen the syndrome manifest itself in a variety ways., an inflammatory illness that causes inflammation in the blood vessels, particularly the coronary arteries.
"We really have a way of ... identifying them early, treating them early so that kids don't get sicker," said Karen Smith, the chief of hospitalist medicine at Children's. The majority of the hospital's MIS-C patients do not test positive for the coronavirus, yet they have the antibodies that signal they've recovered from the virus. That implies a post-infection response in which kids' immune systems are overreacting to the coronavirus after fighting off an active infection, DeBiasi said.
"There does seem to be more infection and severity in some of the racial or ethnic groups or perhaps even genetic predispositions," she said. However, given the uncertainty, doctors at Children's say they are trying to be conservative when it comes to diagnosing MIS-C because the treatments involved can strain young, growing bodies.
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