Each vaccine development initiative begins with a careful risk-benefit analysis, and the stakes – life and death – could not be higher.
MORE: Vaccine paradox: Will 'flattening the curve' stymie the chances of developing a coronavirus vaccine quickly?
of 1918 and 1919 had taken the lives of some 675,000 Americans and 50 million worldwide, surpassing the casualty count from the recently concluded First World War and dwarfing the human toll of the current pandemic. The St Louis Red Cross Motor Corps on duty with mask-wearing women holding stretchers at the backs of ambulances during the Influenza epidemic, St Louis, October, 1918.
Oshinsky said Park’s vaccine “failed miserably” as a result of limitations in the scientific community’s knowledge of the vaccine -- a feature present in today’s vaccine race. But the improbable story of Salk’s triumph often omits a noteworthy failure and what experts say remains one of the most tragic in pharmaceutical history. It happened in 1955, just weeks after Salk’s vaccine earned approval for distribution.
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