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Efficacy and safety of prone position in COVID-19 patients with respiratory failure: a systematic review and meta-analysis - European Journal of Medical ResearchBackground Prone position has already been demonstrated to improve survival in non-COVID acute respiratory distress syndrome and has been widely performed in COVID-19 patients with respiratory failure, both in non-intubated and intubated patients. However, the beneficial effect of the prone position in COVID-19 pneumonia still remains controversial. Therefore, we aimed to evaluate the effectiveness and safety of the prone position compared with the non-prone in non-intubated and intubated COVID-19 patients, respectively. Methods We searched the MEDLINE, EMBASE, and Cochrane databases, as well as one Korean domestic database, on July 9, 2021, and updated the search 9 times to September 14, 2022. Studies that compared prone and non-prone positions in patients with COVID-19 were eligible for inclusion. The primary outcomes were mortality, need for intubation, and adverse events. Results Of the 1259 records identified, 9 randomized controlled trials (RCTs) and 23 nonrandomized studies (NRSs) were eligible. In the non-intubated patients, the prone position reduced the intubation rate compared with the non-prone position in 6 RCTs (n = 2156, RR 0.81, P = 0.0002) and in 18 NRSs (n = 3374, RR 0.65, P = 0.002). In the subgroup analysis according to the oxygen delivery method, the results were constant only in the HFNC or NIV subgroup. For mortality, RCTs reported no difference between prone and non-prone groups, but in NRSs, the prone position had a significant advantage in mortality [18 NRSs, n = 3361, relative risk (RR) 0.56, P | 0.00001] regardless of the oxygen delivery methods shown in the subgroup analysis. There was no RCT for intubated patients, and mortality did not differ between the prone and non-prone groups in NRSs. Adverse events reported in both the non-intubated and intubated groups were mild and similar between the prone and non-intubated groups. Conclusion For non-intubated patients with COVID-19, prone positioning reduced the risk of intubation, particular
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Will Lunar New Year travel cause Covid catastrophe in China?It's the first day of China's Lunar new year holiday - traditionally a day when people make up to 2 billion trips across the country to visit their home towns. But this year it's happening in the shadow of soaring Covid cases. fatimamanji reports.
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Ginger supplement significantly reduced length of hospital stay in individuals with COVID-19 - Nutrition & MetabolismBackground Evidence from previous studies has suggested that ginger extract exhibits the potential as an alternative treatment for Coronavirus disease 2019 (COVID-19). Here, we want to investigate whether ginger supplement improves the clinical manifestation of hospitalized COVID-19 individuals. Methods A total of 227 hospitalized individuals with COVID-19 were randomized to either the control (n = 132) or intervention group (n = 95). The intervention group took ginger supplement orally at the dosage of 1.5 g twice daily, until they were discharged from the hospital. Both groups received the same standard of general medical care during hospitalization, and the length of stay was recorded and compared between groups. Results Among all participants, a significant reduction in hospitalization time (the difference between the treatment and control groups was 2.4 d, 95% CI 1.6–3.2) was detected in response to the ginger supplement. This effect was more pronounced in men, participants aged 60 years or older, and participants with pre-existing medical conditions, relative to their counterparts (P-interactions | 0.05 for all). Conclusion Ginger supplement significantly shortened the length of stay of hospitalized individuals with COVID-19. Trial registration: The trial was registered on the Chinese Clinical Trial Registry (ChiCTR2200059824).
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The Chinese Communist Party plans to avoid a zero-covid reckoningLike Chairman Mao, Xi Jinping seems to believe that China’s rise trumps individual suffering
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'Surveillance programme' to begin random COVID tests for travellers from mainland China to UKAs incidents of COVID infection soar across China, the UK Health Security Agency launches a new testing system at Heathrow, which will also help to identify new variants.
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Thousands cross Hong Kong-China border as Covid restrictions end\n\t\t\tKeep abreast of significant corporate, financial and political developments around the world.\n\t\t\tStay informed and spot emerging risks and opportunities with independent global reporting, expert\n\t\t\tcommentary and analysis you can trust.\n\t\t
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