Scientists deliberately infected young, healthy volunteers with SARS-CoV-2, the coronavirus that causes COVID-19 – and now, they've shared their first results from that experiment.
called D614G. This mutation affects the spike protein, which the virus uses to infect cells, and is thought to increase the virus's transmissibility.
. Roughly a third of the infected participants lost their sense of smell; for 10 of these people, their senses of smell returned to normal within three months, but the final three still experienced deficits at that point.Thankfully,"there were no severe symptoms or clinical concerns in our challenge infection model of healthy young adult participants," the trial's chief investigator, Dr.
In the 18 infected participants, the average incubation period – the time period from initial exposure to first detection of the virus via tests – was 42 hours, the team reported. The researchers took swab samples from the participants' throats and noses twice a day and calculated the amount of viable, or infectious, virus present using PCR tests and laboratory assays.
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