Physical cues in the womb, and not just genetics, influence the normal development of neural crest cells, the embryonic stem cells that form facial features, finds a new study led by UCL researchers.
Apr 23 2024University College London
The researchers found that when neural crest cells are exposed to higher-than-usual levels of pressure, key cell signaling pathways are impeded, and the risk of craniofacial malformations significantly increases. "When an organism is experiencing a change in pressure, all the cells – including the embryo inside the mother – are able to sense it.
Cell Cell Biology Embryo Embryonic Stem Cells Genetics Research Stem Cells
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