The woman was part of a group of families genetically predisposed to developing Alzheimer's in their forties.
, where her thinking skills had waned—but not to a level warranting a dementia diagnosis.
Carrying the rare mutation might have prevented the tau protein, whose tangles are linked to Alzheimer's disease, from collecting in her brain, the researchers concluded.Newsweek "We are working on experimental paradigms to put those drugs to the test when they are available in persons with one or two copies of the APOE4 gene, the major genetic risk factor for developing Alzheimer's at older ages," he said.
"The researchers identified a gene mutation that has protected against the brain cell damage that usually follows amyloid plaques, giving greater insight into the biological mechanisms at play in Alzheimer's disease."
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