A new study explains why some people suffer more from COVID-19 than others. Many people are currently catching COVID-19. Luckily, the majority of them are experiencing only mild symptoms. However, for some people, the disease takes a much more severe cause and our understanding of the underlying re
A new study explains why some people suffer more from COVID-19 than others.. Luckily, the majority of them are experiencing only mild symptoms. However, for some people, the disease takes a much more severe cause and our understanding of the underlying reasons is still insufficient. The human genome may hold a key to why COVID-19 is more serious for some individuals than others.
Previously, the Computational Medicine Group at BIH had developed a ‘proteogenomic’ approach to link protein-encoding regions ofto diseases via the protein product. In this new study, they applied this method to COVID-19 and came across eight particularly interesting proteins. “One of these was a protein responsible for an individual’s blood group,” Claudia Langenberg, head of the Computational Medicine Group, explains.
But Conrad puts a damper on any hopes that the researchers may have identified a new target molecule for drug development: “ELF5 is what is known as a transcription factor, and controls how frequently or infrequently other genes are switched on and off throughout the body,” he explains. “Unfortunately, it is difficult to imagine interfering with this protein in any way, as that would undoubtedly cause many undesirable side effects.
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