Some escape COVID-19 unharmed. The answer might be in their genes.
So far, the most obvious gene involved in the different reactions people have to COVID-19, sits on chromosome 3, and affects the entry of the virus into cells. People with one genetic variant seem to be less likely infected and less likely to show severe consequences from infection,Assuming this genetic connection is confirmed, researchers could look for a drug that creates the same benefit as the mutation.
If blood type turns out to be involved in the seriousness of a patient's response to COVID-19, it could be one factor used to decide whether a hospitalized patient needed relatively aggressive care, added Franke, who plans to dig deeper into the genetics of other blood groups. It's the complexity of the disease and people's reaction to it that demand such large sample sizes, Daly said. A large group will allow for variations in patient age, sex, preexisting conditions and immune status, among other factors.Daly helps lead a group of more than 1,000 scientists at 150 institutions all over the world who are collaborating to get the volume and diversity of records they need to truly understand the effects of COVID-19.
But still, he's not sure where the money will come from to analyze the thousands of genetic samples he hopes to get. He and his colleagues decided to pursue the work now and worry about grant funding and other financial sources later.Italian researcher Alessandra Renieri, director of the Medical Genetics Unit at the University Hospital of Siena, is taking a different approach.
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