More than four years after the first children with edited genomes were born, genome-editing techniques are still not safe enough to be used in human embryos that are destined for reproduction
The statement came at the end of a day of discussion and debate in London about the potential of altering the genomes of either embryos or reproductive cells, called gametes, in ways that would be passed down to future generations. Many of the talks at the meeting were focused on technical and scientific challenges, such as the uncertain consequences of breaking both strands of the DNA double helix — a necessary step in some forms of genome editing — in embryos.
In addition to those challenges, society must grapple with questions about whether the technology should be deployed, organisers said: “Governance frameworks and ethical principles for the responsible use of heritable human genome editing are not in place.”Some researchers have argued that heritable genome editing could help people who carry genetic diseases to avoid passing those conditions on to their children.
In addition to broader concerns about ethics and social justice, editing embryos would require a safe and effective genome-editing platform to minimize the chances of harming the embryo, the resulting child, and that child’s descendants. Most research on genome editing in embryos, however, has been done using animal models such as mice, which might not accurately reflect what happens in human embryos.
Only a handful of laboratories have directly tried to edit the genomes of human embryos using the popular editing system CRISPR-Cas9, and several of these presented concerning results at the summit.The Cas9 enzyme works by breaking both strands of DNA at a site designated by a guiding piece of RNA.
Egli and other researchers also reported on the consequences of the double-strand breaks made by Cas9. Developmental biologist Kathy Niakan at the University of Cambridge, UK, recounted her lab’s experience with
日本 最新ニュース, 日本 見出し
Similar News:他のニュース ソースから収集した、これに似たニュース記事を読むこともできます。
How Spirited Away Changed Animation ForeverSpirited Away is Studio Ghibli's most successful movie and one of the best Hayao Miyazaki movies, introducing elements that changed animation forever.
続きを読む »
Stranger Things: Millie Bobby Brown Ready to 'Create Stories Myself'ICYMI: StrangerThings star MillieBobbyBrown on why she's ready to wrap the series (and why she wouldn't mind joining HBO's TheWhiteLotus). / StrangerThings5 ST5 Netflix
続きを読む »
If the brain doesn't feel pain, why do headaches hurt?The brain doesn't have its own pain receptors, so why do headaches hurt so much?
続きを読む »
How and why do stablecoins depeg?Stablecoins are designed to maintain a ‘stable’ fixed value but sometimes fail. How does this happen, and why? Explore the world of stablecoin depegging.
続きを読む »
One Luther: Fallen Sun Scene Was So Intense A Medic Actually IntervenedOne Luther: The Fallen Sun scene was so intense that a medic actually intervened to secure the life and safety of star Cynthia Erivo.
続きを読む »
Answer Man: Why does it get so humid in the South?Q: Why does it get so humid in the South?
続きを読む »