📹 Professor David Kerr points out that Evusheld trials were done before the Omicron variant dominated. Though real-world data is emerging showing some protection against it, questions remain about duration and who would benefit.
I'm David Kerr, professor of cancer medicine at Oxford. As I'm gearing up to have my autumnal COVID-19 booster vaccine, there's a small controversy raging in the United Kingdom about access to a medicine calledThis was developed by AstraZeneca. It's a combination of two relatively long-acting antibodies that bind to the spike protein on the outside of the SARS-CoV-2 virus, the virus that causes COVID-19.
These are, in the population as a whole, relatively small numbers, but an important number of people who are still vulnerable to developing COVID-19 despite vaccination. The trials with Evusheld were done before the Omicron variant dominated, as it does now; therefore, they are looking to try to work with AstraZeneca to generate more real-world data to show that Evusheld would prevent infection from the Omicron variant of the virus. Equally as important, how long does that protection last? Is it as protective against Omicron, and what's the duration of that protection? Those bits of work are going on now.
Wanting to damp down this controversy, perhaps the sensible thing would be to ask NICE to evaluate the data that they have just now, to allow AstraZeneca to present whatever real-world evidence they have, and although it may not be perfect, it may be sufficient — we don't know — to pass the NICE health technology assessment.
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