People taking an SSRI antidepressant do less well in a task that measures how sensitive we are to rewards
One task measured how well they learned from rewards, with people having to repeatedly choose between two stimuli. Through trial and error, they generally learned that one stimulus led to a reward more often than the other. Then the probabilities of a reward for each stimulus would switch and the participants had to learn this new system.
The finding suggests that SSRIs reduce people’s sensitivity to rewards or other pleasurable experiences, says Sahakian. But the medicines can also blunt the intensity of negative feelings, which can be helpful, she adds. “I hope this doesn’t make doctors more cautious about prescribing antidepressants as they’re extremely important drugs,” she says. “I hope it would make doctors have a discussion with patients about potential side effects.”
“Why antidepressants cause emotional blunting in a subset of people is a really important question,” saysat the University of Oxford. “I don’t think this result explains why people have this effect, but it may be a marker of it, which could be useful when we come to develop new treatments that don’t have it.”
Harmer says the study would have been more useful if the participants had also been asked if they experienced blunted emotions while taking the antidepressant.
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