Vocacapsaicin, an experimental non-opioid painkiller, improved analgesia and decreased opioid use in patients undergoing bunionectomy compared with placebo.
Compared with placebo, administration of vocacapsaicin during bunionectomy reduces pain and decreases opioid consumption in the first 96 hours after surgery, with no local or systemic toxicity.This triple-blinded, randomized, placebo-controlled trial included 147 patients undergoing bunionectomy.
Patients were randomly assigned to receive 14 mL of either 0.05 mg/mL vocacapsaicin, 0.15 mg/mL vocacapsaicin, 0.30 mg/mL vocacapsaicin, or placebo at the surgical site duringPatients were observed for 96 hours post-surgery, with follow-up visits on days 8, 15, and 29 to monitor for pain and adverse events.
The primary endpoint was overall levels of pain at rest through the first 96 hours after surgery for the 0.30 mg/mL vocacapsaicin group. The secondary endpoints included the percentage of patients who did not require opioids and total opioid consumption through 96 hours, as well as pain scores during the first postoperative week.Vocacapsaicin reduced pain at rest by 33% over the first 96 hours compared with placebo (Overall, 26% of patients who received the 0.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Pain Hallux Valgus Bunion Opioids Analgesia Analgesic Painkiller Surgery Perioperative Artificial Intelligence Deep Learning AI NPL Machine Learning ML Natural Language Processing Artificial Neural Networks California Postoperative Wound Healthcare And Medical Technology Health And Medical Tech Health And Med Tech Health And Medical Technology Healthcare Technology
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