Is vitamin D a viable strategy for dementia prevention? NeuroTwitter Dementia
The findings are based on 12,388 adult participants in the US National Alzheimer's Coordinating Center database who had normal cognition or mild cognitive impairment at the outset. A total of 4637 took vitamin D supplements, and 7751 did not.
After adjusting for age, sex, education, race, cognition, depression, and APOE4 status, vitamin D exposure was significantly associated with a lower incidence of dementia . They caution that the study has several limitations. They were no data on dose or duration of vitamin D exposure or baseline serum vitamin D levels."Clarifying exposure duration, dose-response relationships, and the role of vitamin D deficiency will be necessary to inform intervention studies," the researchers note.
"We know that people with low vitamin D are at higher risk of developing cognitive problems. That's been reproducible in multiple epidemiological studies. But if we take people with normal vitamin D levels and supplement with vitamin D, do we lower their risk of future cognitive impairment? I think that's where the controversy lies," Hajjar, who wasn't involved in the study, told Medscape Medical News.
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