Vaccine companies searching for 1-shot dose of COVID-19 vaccine.
New vaccine technologies are, however, being developed -- ones that only need one shot, but generate a sustained, yet controlled, immune response.
For example, the Arcturus vaccine developed by Payne and his colleagues uses a special technique. The vaccine contains a small piece of genetic material, which not only instructs the body to produce a protein that will trigger an immune response, but also adds an extra packet of instructions that effectively helps turbocharge the amount of protein produced.
The company logo for Johnson & Johnson is displayed on a screen to celebrate the 75th anniversary of the company's listing at the New York Stock Exchange in New York, Sept. 17, 2019. The company logo for Johnson & Johnson is displayed on a screen to celebrate the 75th anniversary of the company's listing at the New York Stock Exchange in New York, Sept. 17, 2019.But with current data, it isn't clear whether the vaccine can generate immunity after just one dose. Amidst ongoing questions about the nature and duration of coronavirus immunity, it might be the case that these vaccines will need booster doses later down the line.
"There are two aspects of vaccine durability -- one is the antibody response, the other is the T-cell response," Payne told ABC News."Most vaccines generate antibodies, but what everyone wants to get is T-cells. If you can do both, you can use a single shot and be done."Editor's Picks
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