CRISPR-Cas9 gene editing holds immense potential in the field of precision medicine for liver diseases.
Liver diseases: The need for innovative treatmentsFuture prospects and research directions This innovative technology permits researchers to precisely modify genes linked to liver conditions, ultimately offering hope for targeted treatments.Introduction to CRISPR-Cas9 gene editing The science of genetic engineering has been revolutionized by the groundbreaking CRISPR-Cas9 gene-editing technique. This system differs from other methods by using RNA instead of a protein to identify DNA.
Since its discovery in 1987, the CRISPR-Cas9 gene-editing system has undergone a remarkable journey of development. The foundational work began with Yoshizumi Ishino, who first identified the unique repetitive DNA sequences in the genomes of bacteria. However, it wasn't until 2012 that CRISPR-Cas9's true potential was unveiled by Jennifer Doudna and Emmanuelle Charpentier.
These diseases can be caused by viral infections, alcohol consumption, obesity, autoimmune disorders, genetic and environmental factors. One example of a liver disease that has gained significant attention is NAFLD. It is closely associated with metabolic syndrome and ranges from simple fatty liver, which can progress to non-alcoholic steatohepatitis , fibrosis and eventually cirrhosis.
CRISPR-Cas9 applications in liver disease CRISPR-Cas9 has been of particular interest in the field of liver research. For example, hepatitis B virus -associated diseases are primarily caused by the persistence of HBV covalently closed circular DNA in hepatocytes. Current antiviral therapies ide analogs) are effective in inhibiting HBV replication, but are unable to eliminate cccDNA, making it a major barrier to eradicating chronic hepatitis B.
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