Some patients with uncontrolled neovascular age-related macular degeneration achieved a reduction in disease activity and gains in visual acuity after switching to the biologic agent brolucizumab, according to a new study presented ARVO2023. nAMD
April 25, 2023
"The study shows there's a benefit; I can recommend this treatment," said Tadayoni, who also is a professor at the University of Paris. The drug works against vascular endothelial growth factor attached to a human single-chain antibody fragment, allowing for greater dosing of anti-VEGF per volume. Since its release, brolucizumab has come under scrutinySWIFT is an ongoing 48-week, single-arm, open-label study conducted across 52 sites in France. All patients in the trial had active choroidal neovascularization lesions diagnosed within the previous 18 months while undergoing treatment every 4 or 8 weeks.
The proportion of patients with no disease activity at week 16 was 40.4%, with consistent benefit across subgroups. A mean increase from baseline in BCVA of 4.1 letters was also observed as was a mean decrease in CSFT of −51 µm, according to the researchers. While 85% of patients had SRF fluid at baseline, this figure dropped to 53% at week 16; the incidence of dry retina improved from 1.4% at baseline to 31.3% after treatment, Tadayoni's group reported.
The committee confirmed intraocular inflammation-only in 20 patients, inflammation plus retinal vasculitis in six , and inflammation plus retinal vascular occlusion in two . One patient had inflammation plus both retinal vasculitis and retinal vascular occlusion. For these events, the incident rate per 1000 injections was, respectively, 12.50, 3.75, 1.25, and 0.63, Tadayoni reported.
日本 最新ニュース, 日本 見出し
Similar News:他のニュース ソースから収集した、これに似たニュース記事を読むこともできます。
Rainy Sunday kicks off week of wet weather for Harrisburg area: forecastersMost days this week will feature a chance of rain, according to the National Weather Service.
続きを読む »
Rain likely almost all week after wet weekend in central Pa.More than 20 mph winds could also lash the midstate for several days.
続きを読む »
Record heat possible; Cool & wet later this weekGood morning! The first day of May may feel like summer, with near-record heat possible this afternoon in northern Utah. Temperatures could climb to the upper 80s! FULL FORECAST:
続きを読む »
Wet, Cool And Windy Pattern Starts May | Weather.comA wet, cool and miserable start to May is expected in the eastern United States due to a blocking pattern. - Articles from The Weather Channel | weather.com
続きを読む »
This Piping-Hot Rocky World Looks Surprisingly WetWebb Telescope observations reveal water vapor near a distant exoplanet—but could the signal actually be coming from the star?
続きを読む »
See Rushing Waterfalls and Submerged Roads as California FloodsThe record-breaking snowpack is melting with higher spring temperatures after a super-wet winter.
続きを読む »