A 'two-for-one' cancer immunotherapy is potentially more effective and at least as safe as standard immunotherapies, physician-scientists from UPMC Hillman Cancer Center who led an international, early-phase clinical trial report today in the journal Nature Medicine.
Reviewed by Lily Ramsey, LLMOct 19 2023 A "two-for-one" cancer immunotherapy is potentially more effective and at least as safe as standard immunotherapies, physician-scientists from UPMC Hillman Cancer Center who led an international, early-phase clinical trial report today in the journal Nature Medicine.
Jason Luke, M.D., lead author, director of the Immunotherapy and Drug Development Center at UPMC Hillman and associate professor of hematology and oncology at the University of Pittsburgh School of Medicine Luke says one drug doing the work of two may be better than two separate drugs, which might engage the immune system differently. When two drugs are used, they may not specifically bind together on the same immune cells. When one bispecific drug with two immune molecules binds to immune cells, the interactions are different and potentially generate greater immune activation.
The research team took the trial a step further and enrolled another 84 patients with advanced cancers positive for a protein called HER2 to test tebotelimab combined with an approved drug for HER2-positive cancer, called margetuximab. The response rate in those participants was 19%, which Luke said was impressive given the response rate is usually closer to 0% in these particular patients.
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Cancer drug that targets two immune-evading tumor tactics performs well in early clinical trialA 'two-for-one' cancer immunotherapy is potentially more effective and at least as safe as standard immunotherapies, physician-scientists from UPMC Hillman Cancer Center who led an international, early-phase clinical trial report in the journal Nature Medicine.
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