Anti-wrinkle creams, superfoods that keep you young, dietary supplements that promise improved memory, 'immortal' cells that can renew themselves forever-;in our stores and media, claims about aging abound.
Reviewed by Lily Ramsey, LLMNov 2 2023 Anti-wrinkle creams, superfoods that keep you young, dietary supplements that promise improved memory,"immortal" cells that can renew themselves forever-;in our stores and media, claims about aging abound.
And the hub of it all is one of the largest research centers in the world that focuses on healthy aging and its relationship to nutrition and physical activity: the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts. Booth also pointed out that one in five people aged 65 or older remain in the workforce, which raises questions about how to accommodate different generations with different skills, experiences, work philosophies, and physical needs in the workplace."Aging is the new reality," Booth said."And most people aren't even thinking about the implications for society."
"We associate these chronic degenerative diseases with aging, because their incidence rates increase exponentially among older people," Wiley said."The basic processes that underlie aging can drive chronic degenerative conditions. But chronic degenerative conditions are not aging, per se." Sixty-five is also a common cutoff in research on older adults, Booth said-;although studies of older women often use menopause, because it's a distinct, measurable event that changes aging. Studies of sarcopenia, or muscle wasting, often focus on adults in their 80s and 90s, which is the period when that disease tends to develop."It really depends on the scientific question," Booth said.
The same thing happens to the human body."There's damage to your cells happening all the time," Wiley said. Except the body, with its many interlinked processed, systems, and levels of organization, is much more complex than a car-;and therefore has many more points of potential failure. "It can start with something as simple as a broken molecule, one little thing that goes wrong in one cell, and then it's like the butterfly effect," Wiley said."The tissue starts struggling, and then the organ, and then your entire body."
But there's a fundamental limitation to studying how to make human lives longer."We don't get grants for a hundred years," Wiley said."And who's going to do it?" "Healthspan" has promise as a term for our years free of disability, Booth noted-;but it doesn't cover the increasing numbers of older adults who are losing their health but retaining their abilities through the new field of gerotechnology, which spans smartphone features, ambient systems, robotics, artificial intelligence, and more."We are continuously moving that threshold of that ability to live independently," Booth said."It's a really exciting time.
One of these things is diet, which the HNRCA is now studying in greater depth than ever before. One of six institutes nationwide to receive a grant from the National Institutes of Health-;in the amount of $8.5 million-;for the cutting-edge field of precision nutrition, the HNRCA is embarking on a major study of how and why certain diets have different effects on individuals' aging and other biological processes.
"We're bringing the broader sociological demographics to our research to understand why some groups in the population have accelerated aging compared to others," Booth said."We're bringing in engineers, mathematicians, artificial intelligence, and machine learning to look for patterns and predictive algorithms in the data from all these different disciplines."
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