Tuft cell–produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation

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Tuft cell–produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation
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In mice, IL-25 and CysLTs proteins from airway TuftCells cooperate to drive Allergen inflammation in the lungs, say researchers in SciImmunology.

We thank A. Chicoine from Brigham and Women’s Hospital Human Immunology Center Flow Core for help with FACS. We are grateful to C. Vidoudez and S. Trauger from the Harvard Center for Mass Spectrometry and Oswald Quehenberger from the University of California San Diego Lipidomics Core for expertise and help in setting up the mass spectrometry assays for CysLTs and lipidomics assays. We are also thankful to L.

The RNA-seq data for this study have been deposited to the NCBI Gene Expression Omnibus and are accessible under accession number GSE188820. All other data needed to evaluate the conclusions in the paper are present in the paper or the Supplementary Materials.mice are available from I.M. under a material transfer agreement with the Monell Chemical Senses Center.

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