Tiny 'bacterial syringes' could deliver proteins to individual human cells

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Tiny 'bacterial syringes' could deliver proteins to individual human cells
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'This is a really beautiful example of how protein engineering can alter the biological activity of a natural system.'

Re-engineered syringe had no negative side effects

In the lab, the re-engineered syringe was tested on mice and human cells. It had no negative side effects on the surrounding cell environment.Initial results suggest that it could be used to help deliver treatments directly into human cells in the future. According to the release, the syringe can be programmed to deliver a variety of proteins, including those for gene editing as well as can be used for different cell types.

"I think it substantiates protein engineering as a useful tool in bioengineering and the development of new therapeutic systems,” said Kreitz. The breakthrough could pave the way for the development of more effective treatments for a variety of diseases, including cancer. Moreover, the innovation could also lead to the development of personalized medicines.Endosymbiotic bacteria have evolved intricate delivery systems that enable these organisms to interface with host biology.

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