Doctors and the U.S. FDA say they have received multiple reports of people on the blockbuster drugs experiencing stomach paralysis that sometimes has not resolved by the time it’s reported. They took Ozempic or Wegovy. Now their stomachs are paralyzed:
Joanie Knight has a message for anyone considering drugs like Ozempic or Wegovy, which have become popular for the dramatic weight loss they can help people achieve.
So far, extreme and unrelenting cases like these are believed to be rare, and they may be a result of the drug unmasking or worsening an existing “slow stomach.” Doctors say people can have a silent condition called delayed gastric emptying and not know it. There’s nothing on the drugs’ labels that specifically cautions that gastroparesis may occur.
On the other hand, this is how the drugs work, although not many doctors or patients understand this or the problems that may follow, he said.how one of the first GLP-1 agonists, a drug called liraglutide, affects stomach function. Fortunately, people in the study seemed to adjust to the medication over time. After 16 weeks, people in the group taking liraglutide were clearing about half the food they ate from their stomachs in about 30 minutes, as opposed to seven minutes in the placebo group. Symptoms of nausea and vomiting seemed to ease, too.
A gastric emptying study — a test that measures how food moves through the stomach — put Knight in the severe category. She said she stayed nauseated all the time, no matter how little she ate, and took a prescription anti-nausea medication “like it was candy.”prescription information In September 2020, Wright had to be hospitalized for dehydration related to the vomiting, and that prompted her to push her doctors for more answers. A gastric-emptying study showed that she had gastroparesis. Her doctors put her on two more medications to try to help her manage her symptoms but didn’t take her off the Ozempic because they didn’t suspect it was contributing.
Then, instead of just vomiting the food she’d recently eaten, Wright noticed that she was throwing up food she’d eaten three or four days prior.“Then the GI doctor said, ‘Well, I’ve been seeing a lot of clients coming in with full stomachs on endoscopy who are on Ozempic. So let’s try taking you off the Ozempic,’ ” Wright said.
Knight eventually had stomach bypass surgery. It’s similar to the technique used for weight loss, but it can also be a treatment for severe cases of gastroparesis. She said it has allowed her to eat some of her favorite foods again, like a few bites of pizza or chicken. The FDA said it has been unable to determine whether the medications were the cause or if the gastroparesis may have been caused by a different issue.
The FDA said people with gastroparesis weren’t excluded from clinical trials of these medications, and the benefits for diabetes and weight management “may outweigh the risks in some patients with gastroparesis or delayed gastric emptying.” “In my experience, when you stop the GLP-1 agonist, the gastric emptying improves, and it gets better,” said Nguyen, who is also a spokesperson for the American Gastroenterological Association.Anesthesiologists say there are real hazards involved with stomach paralysis on these medications, and doctors and patients need more information about the risks.
She said that as more and more people take these medications, with little information about the stomach slowdown that comes with them, they may not know to tell their doctors.
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