Less than a third of heavily advertised drugs have 'high therapeutic value': study jamanetworkopen JAMA_current
describe this process and illustrate the inclusions and exclusions that arrived at our final cohort of 81 drugs.
For each drug indication, we obtained therapeutic value ratings from independent health technology assessment agencies of Canada, France, and Germany and defined ratings of moderate or greater therapeutic value as high therapeutic value, using methods described previously.Ratings consider drugs’ added benefit, safety, and strength of evidence, as compared with existing therapies. We used the most favorable rating available in cases of reevaluations or multiple ratings for a single indication .
We first assessed the proportion of commonly advertised drugs rated as high therapeutic value by any agency. We then examined drugs that were rated by at least 2 agencies. Analyses were conducted using Excel version 16.67 . The study was exempt from institutional review board review and the requirement for informed consent, as no patient data were used.
The findings of this study are consistent with prior research that questioned the therapeutic value of drugs heavily promoted to clinicians.One explanation might be that drugs with substantial therapeutic value are likely to be recognized and prescribed without advertising, so manufacturers have greater incentive to promote drugs of lesser value.
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