Accelerating research by sharpening the focus on unknown proteins. UK researchers have developed a new publicly accessible database, and they hope to see it shrink over time. That’s because it is a compendium of the thousands of understudied proteins encoded by genes in the human genome, whose exis
Researchers from the UK have developed a publicly accessible database, the “unknome”, which lists thousands of understudied proteins encoded by human genes. By assigning a “knownness” score to each protein based on existing scientific knowledge, the platform aids researchers in exploring these proteins’ functions, many of which play critical roles in cellular processes.UK researchers have developed a new publicly accessible database, and they hope to see it shrink over time.
The sequencing of the human genome has made it clear that it encodes thousands of likely protein sequences whose identities and functions are still unknown. There are multiple reasons for this, including the tendency to focus scarce research dollars on already-known targets, and the lack of tools, including antibodies, to interrogate cells about the function of these proteins.
To test the utility of the database, the authors chose 260 genes in humans for which there were comparable genes in flies, and which had knownness scores of 1 or less in both species, indicating that almost nothing was known about them.
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