Here are the ForbesUnder30 alums racing to develop at-home coronavirus tests with the gene-editing technology Crispr:
Mammoth Biosciences CEO Trevor Martin describes the current Covid-19 diagnostics landscape as a “tale of two cities.” His hope for Crispr-based diagnostics is to “unite” the accuracy of molecular tests with the speed of serology tests.
The benefit of Mammoth’s diagnostics platform, known as DETECTR, is it can quickly adapt to new diseases by switching out the Crispr enzymes and target sequences, which is what happened in January as the company pivoted to develop a Covid-19 test. Less than three months later, Mammoth’s CTO Janice Chen co-authored a paper published in, demonstrating the platform could detect the virus with a high-level of accuracy in less than 40 minutes across 83 patient samples.
Omar Abudayyeh and Jonathan Gootenberg frequently use the word “simple” when describing the vision for their Crispr-based diagnostic test for Covid-19. Picture a device, they say, about the size of an iPhone. A person will insert a nasal swab or spit sample into it, and, within twenty minutes or so, the device will indicate whether the person has Covid-19. The results, printed on a strip of paper, will be easy to understand: one line and its negative, two lines and its positive.
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