The safety and preliminary efficacy of OP-101 in patients with severe COVID-19 ScienceTM ScienceMagazine UTAustin HopkinsMedicine AveraHealth BrowardHealth COVID19 coronavirus covid virus nanotherapy
By Bhavana KunkalikarAug 8 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in Science Translational Medicine, researchers assessed the impact of dendrimer nanotherapy in treating severe coronavirus disease 2019 .
The study involved 24 patients having a World Health Organization seven-point ordinal scale score of five and more who were enrolled at five centers in the US from August 2020 and March 2021. The participants were enrolled in three cohorts based on the doses administered. After the assessments for each dose level were completed on day 3, the laboratory and clinical data were reviewed by the independent data monitoring committee , and dose escalation was performed after each review.
Results Related StoriesThe study results showed that more men were enrolled with severe COVID-19 compared to women, indicating that men were at a higher risk of experiencing increased disease severity. Almost 14 of the total 24 patients displayed diabetes as a comorbidity. Notably, patients aged more than 45 years and those who had comorbidities like obesity and diabetes mellitus were more likely to have increased disease severity.
Furthermore, there was a higher increase in the serum levels of NfL in the placebo cohort compared to the OP-101-treated cohort. The rate of change observed was 14.4% per day in the placebo group as compared to the treated group, with a remarkable difference observed for the two highest treatment doses of +3.3% for the 4 mg/kg and +0.2% for the 8 mg/kg cohorts.
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